Neural tube defaults (NTDS), also known as neural tube deformity, is a type of congenital defect caused by incompleteness caused by early nerve tube closure. The main clinical types include brain -free, spine bales and brain swelling.
Folic acid lacks the mechanism to increase neural tube malformations: the height of the same cysteine to increase the DNA synthesis and DNA methylation abnormality, which affects the gene expression and migration or proliferation of nerve cells related to the formation of nerve tube, which hinders the closing of the nerve tube.EssenceFor preparation or early pregnancy, supplementing folic acid is one of the effective measures to prevent the defects of this birth.
But for different small masters, the dosage of folic acid is different.
1. Small master with no high -risk factors: It is recommended to add 0.4 mg or 0.8 mg folic acid daily from possible to at least 3 months before pregnancy or before pregnancy, until 3 months of pregnancy.
2.Small master who has a history of neural tube defect: It is recommended to increase 4mg of folic acid daily from possible to at least one month before pregnancy or before pregnancy until the pregnancy is 3 months.Given that there is no 4mg in China and has a 5mg folic acid agent type, 5 mg folic acid can also be added daily.
3.The husband and wife suffer from neuroterse defects or men who have had a history of neurotic defects in the past: It is recommended to increase 4mg of folic acid daily from possible pregnancy or at least one month before pregnancy, until 3 months of pregnancy.
4.Urominic hydrocephalus, congenital heart disease, cleft lip and palate, limb defects, urinary system defects, or the above -mentioned defect family history, or women with a history of neural tube defects in the first- and second -level direct relatives: It is recommended to get pregnantOr start at least 3 months before pregnancy, add 0.8-1.0mg folic acid daily until 3 months of pregnancy.
5.Small masters with diabetes, obesity or epilepsy: It is recommended to add 0.8-1.0mg folic acid daily from might or at least 3 months before pregnancy or before pregnancy until 3 months of pregnancy.
6.Small masters who are taking fetal neurophastin risk -risk drugs: are taking Kasari Ping, propyate, sodium benzyl, pipyone, phenobrid, dizate, oxyate, oxyline pyridine, methaxed oxygen, oxygen,Women with drugs such as amine, amphenyl, and hypenerine, are recommended to add 0.8-1.0 mg folic acid daily from possible pregnancy or before pregnancy at least 3 months before pregnancy until 3 months of pregnancy.
7.Small master of adverse diseases with gastrointestinal tract: It is recommended to add 0.8-1.0mg of folic acid daily from possible to at least 3 months before pregnancy or before pregnancy until 3 months of pregnancy.
8. If the little master has the following situations, you can add supplementary doses as appropriate or extend the time before pregnancy: ① Living in the north, especially the northern rural areas; ② The amount of fresh vegetables and fruits in the diet is small;Genate; ⑤ Short pregnancy time.
9. For women with high same cysteine, it is recommended to add at least 5mg of folic acid daily until the level of bloody cysteine drops to normal before considering conception, and 5mg of folic acid is continuously added dailymoon.
While adding folic acid, the diet cannot be ignored. Small owners should eat more foods rich in folic acid, such as green leafy vegetables and fresh fruits; at the same time, develop a healthy lifestyle, maintain reasonable weight, take comprehensive measures, reduce fetal nerve tube defectsrisks of.
Pregnant mother asked: Is it okay to start eating folic acid in almost 1 month or 40 days?
When eating folic acid, you are not pregnant, do not eat folic acid or stop taking folic acid.In this regard, the answer of Dean Duan Tao for our gynecological department is available for your reference: Do not entangle folic acid without accidental pregnancy. After all, there are folic acid in food. After all, the incidence of neurotic defects is not high. After allExamination found.
The development of neural tube is completed during early pregnancy, so the mission of folic acid prevention of neural tube defects has ended during early pregnancy. At the end of 3 months of pregnancy, can the little master stop oral folic acid?Let’s see Dr. Fu Hong’s decomposition.
References: Adding folic acid prevention neurotic defect guide during pregnancy (2017), China Magazine Magazine, 2017, 28 (5): 401-410
Pay attention to "Dr. Fu Hong" with one click, bringing you healthy and good luck!